| Teams 2010 5-Hour Energy 250 |
|---|
| No. | Team | Driver | Mfg |
|---|---|---|---|
| 1 | JD Motorsports | Mike Wallace | Chevrolet |
| 4 | JD Motorsports | Jeremy Clements | Chevrolet |
| 6 | Roush Fenway Racing | Ricky Stenhouse, Jr. | Ford |
| 7 | JR Motorsports | Danica Patrick | Chevrolet |
| 9 | RAB Racing | Brian Scott | Ford |
| 10 | Turner Scott Motorsports | Scott Wimmer | Toyota |
| 11 | Turner Scott Motorsports | Brad Sweet | Toyota |
| 12 | Team Penske | Justin Allgaier | Dodge |
| 15 | Germain Racing | Michael Annett | Toyota |
| 16 | Roush Fenway Racing | Trevor Bayne | Ford |
| 18 | Joe Gibbs Racing | Brad Coleman | Toyota |
| 20 | Joe Gibbs Racing | Matt DiBenedetto | Toyota |
| 21 | Shepherd Racing Ventures | Morgan Shepherd | Chevrolet |
| 22 | Team Penske | Brad Keselowski | Dodge |
| 23 | R3 Motorsports | Peyton Sellers | Chevrolet |
| 26 | K-Automotive Performance | Brian Keselowski | Dodge |
| 27 | Baker Curb Racing | Drew Herring | Ford |
| 28 | Jay Robinson Racing | Kenny Wallace | Toyota |
| 32 | Turner Scott Motorsports | Reed Sorenson | Toyota |
| 33 | Kevin Harvick Incorporated | Mike Bliss | Chevrolet |
| 34 | TriStar Motorsports | Tony Raines | Chevrolet |
| 35 | TriStar Motorsports | Antonio Perez | Chevrolet |
| 36 | TriStar Motorsports | Kevin Hamlin | Chevrolet |
| 38 | Turner Scott Motorsports | Jason Leffler | Toyota |
| 39 | Go Green Racing | Sean Caisse | Ford |
| 40 | Key Motorsports | Jeff Green | Chevrolet |
| 42 | Smith-Ganassi Racing | Brandon McReynolds | Dodge |
| 56 | Mac Hill Motorsports | Kevin Lepage | Toyota |
| 60 | Roush Fenway Racing | Carl Edwards | Dodge |
| 62 | Rusty Wallace Racing | Brendan Gaughan | Toyota |
| 66 | Rusty Wallace Racing | Steve Wallace | Toyota |
| 70 | ML Motorsports | Shelby Howard | Chevrolet |
| 79 | 2nd Chance Motorsports | Tim Andrews | Ford |
| 81 | MacDonald Motorsports | Michael McDowell | Dodge |
| 87 | NEMCO Motorsports | Joe Nemechek | Chevrolet |
| 88 | JR Motorsports | Josh Wise | Chevrolet |
| 89 | Shepherd Racing Ventures | Johnny Chapman | Chevrolet |
| 90 | D'Hondt Humphrey Motorsports | Danny O'Quinn, Jr. | Chevrolet |
| 91 | Randy Humphrey Racng | Chase Miller | Chevrolet |
| 92 | K-Automotive Performance | Andy Ponstein | Dodge |
| 94 | Danford Motorsports | Carl Long | Dodge |
| 98 | Roush Fenway Racing | Paul Menard | Ford |
| 99 | Michael Waltrip Racing | Ryan Truex | Toyota |