| Teams 2022 Drive for the Cure 250 presented by BlueCross BlueShield of NC |
|---|
| No. | Team | Driver | Mfg |
|---|---|---|---|
| 1 | JR Motorsports | Sam Mayer | Chevrolet |
| 2 | Our Motorsports | Sage Karam | Chevrolet |
| 2 | Richard Childress Racing | Sheldon Creed | Chevrolet |
| 4 | JD Motorsports | Bayley Currey | Chevrolet |
| 5 | BJ McLeod Motorsports | Scott Heckert | Chevrolet |
| 6 | JD Motorsports | Ryan Vargas | Chevrolet |
| 07 | SS Green Light Racing | Andy Lally | Ford |
| 7 | JR Motorsports | Justin Allgaier | Chevrolet |
| 07 | SS Green Light Racing | Joe Graf, Jr. | Ford |
| 8 | JR Motorsports | Josh Berry | Chevrolet |
| 9 | JR Motorsports | Noah Gragson | Chevrolet |
| 10 | Kaulig Racing | Landon Cassill | Chevrolet |
| 11 | Kaulig Racing | Daniel Hemric | Chevrolet |
| 13 | MBM Motorsports / Garage 66 | Timmy Hill | Toyota |
| 16 | Kaulig Racing | AJ Allmendinger | Chevrolet |
| 18 | Joe Gibbs Racing | James Davison | Toyota |
| 19 | Joe Gibbs Racing | Brandon Jones | Toyota |
| 21 | Richard Childress Racing | Austin Hill | Chevrolet |
| 23 | Our Motorsports | Anthony Alfredo | Chevrolet |
| 26 | Sam Hunt Racing | Daniil Kvyat | Toyota |
| 27 | Our Motorsports | Jeb Burton | Chevrolet |
| 31 | Jordan Anderson Racing | Myatt Snider | Chevrolet |
| 34 | Jesse Iwuji Motorsports | Kaz Grala | Chevrolet |
| 35 | Emerling-Gase Motorsports | Brad Perez | Toyota |
| 36 | DGM Racing | Alex Labbé | Chevrolet |
| 38 | RSS Racing | Patrick Gallagher | Ford |
| 39 | RSS Racing | Ryan Sieg | Ford |
| 44 | Alpha Prime Motorsports | Josh Bilicki | Chevrolet |
| 45 | Alpha Prime Motorsports | Stefan Parsons | Chevrolet |
| 48 | Big Machines Racing | Marco Andretti | Chevrolet |
| 51 | Jeremy Clements Racing | Jeremy Clements | Chevrolet |
| 54 | Joe Gibbs Racing | Ty Gibbs | Toyota |
| 66 | MBM Motorsports / Garage 66 | JJ Yeley | Toyota |
| 68 | Brandonbilt Motorsports | Kris Wright | Chevrolet |
| 78 | BJ McLeod Motorsports | Brandon Brown | Chevrolet |
| 91 | DGM Racing | Preston Pardus | Chevrolet |
| 92 | DGM Racing | Josh Williams | Chevrolet |
| 98 | Stewart Haas Racing | Riley Herbst | Ford |